Pharmacological action of chondroitin sulfate

- Aug 24, 2017 -

CS widely exists in human and animal cartilage tissue. Its medicinal preparations mainly contain chondroitin sulfate A and chondroitin sulfate C two isomers, different species, age and other animal cartilage in the content of chondroitin sulfate. Its pharmacological action is as follows:

1. CS can remove lipids and lipoproteins in the body's blood, remove cholesterol from the blood vessels around the heart, prevent atherosclerosis, and increase the turnover of lipids and fatty acids in cells.

2, CS can effectively prevent coronary heart disease. The experimental atherosclerosis model has the function of resisting atherosclerosis and the formation of atherosclerotic plaque, increasing the coronary artery or collateral circulation of atherosclerosis, and accelerating the healing, regeneration and repair of myocardial necrosis or degeneration caused by experimental coronary artery sclerosis or embolism.

3, can increase the cell's Messenger ribonucleic acid (MRNA) and DNA (DNA) biosynthesis and has the role of promoting cell metabolism.

4, anticoagulant activity is low. Chondroitin sulfate has a moderating effect of anticoagulant, each LMG chondroitin sulfate A is equivalent to 0.45U anticoagulant activity of heparin. This anticoagulant activity does not depend on Antithrombin III, which can play a role in anticoagulant activity through the fibrinogen system.

5, chondroitin sulfate also has anti-inflammatory, accelerated wound healing and anti-tumor effects.


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